BioPen application examples

Single-cell signaling

Measuring receptor activation is of critical importance for understanding cell signaling. With BioPen you can directly measure receptor activation kinetics on a single-cell level in the native cell environment, enabling acquisition of more detailed data without ensemble averaging.

Example: Single-Cell Analysis of CXCR4 Receptor Signaling


The BioPen system is a powerful tool for delivering nanoparticles to individual cells to study their interaction in real-time in the cell’s native environment. The BioPen system lets you study these process directly on a single-cell level using very small amounts of expensive or scarce sample solutions. BioPen lets you study a wide range of processes where where the interaction between cells and nanoparticles plays an role, such as viral infection, nanoparticle drug delivery, exosome biology and endocytosis.

Read more: BioPen Nanoparticle Delivery

Cell membrane biology and biophysics

The cell membrane plays an important role in many biological processes and understanding its properties and how it affects cell behavior is central for understanding the biology of the cell as a whole. BioPen lets you not only subject individual cells, vesicles and bilayer structures to various solutions, but also enables you to create patterned lipid membranes and selectively gather single lipid vesicles from a surface.

Read more: Cell Membrane Biophysics

Spatial tissue biology and analysis

Selectively exposing part of a tissue or cell to a specific chemical environment can be an effective way to understand larger-scale biological processes such as cell migration or tissue and organ function. An example of this is using BioPen to selectively deliver blood to the tip of a mosquito blood-sucking needle to study the neurobiology behind blood sensing.

Read more: The Taste of Blood in Mosquitoes

Contact us to learn more about ho you can use BioPen in your research.

Contact Us