Cell by cell – The 3D bioprinting revolution

Biopixlar represents a new paradigm in bioprinting. The open volume microfluidic technology lets you build functional tissues directly using the cells you want – without the need for any bioink or other carrier material.

Thanks to its high precision cell deposition technology, you can bring your detailed tissue designs to life without having to compromise. Read on to find out how we transform medical research and drug development – cell by cell.

Print any cell

The ability print any cell type with single-cell precision opens up a whole new world of possibilities in everything from fundamental biological research to drug development and regenerative medicine. Biopixlar lets you print even the most demanding cell types in any configuration, from single-cell arrays to organoids and complex tissues. The high precision microfluidic cell deposition technology promotes intercellular communication and ensures high cell viability.

Biopixlar has been used to print hepatocytes, beta cells, cardiomyocytes, T-cells, primary neurons, IPSCs, MSCs, corneal cells, melanoma and adenocarcinoma cells, neuroblastomal cells, fibroblasts, renal epithelial cells, keratinocytes, and much more…

Complex tissues

With Biopixlar, the possibilities for design-driven tissue engineering are almost endless. You can arrange multiple cell types in 3D and create complex cellular architectures.

With its precise positioning and cell deposition technologies, cells end up right where you want them to be.

The high resolution bioprinting capacity makes it possible to place cells close to each other, ensuring efficient cell to cell communication.

Read more in our cell microenvironment engineering application note.

Spheroids

Spheroids are a powerful tool for in vitro tissue and disease modeling, with multiple applications across cancer and stem cell research and drug development. With Biopixlar, you can create spheroids to fit your research needs.

Biopixlar’s microfluidic high-precision cell deposition technology lets you control both the size and the cellular composition of the spheroids. Since you perform cell printing directly in culture media without any bioink, cell survivability inside the spheroids is high.

Download our application note.

Cell arrays

Biopixlar’s direct cell deposition technology can be used to create cell arrays that let you set up assays and study biological processes in great detail.

The precise cell placement controls make it possible to create arrays that consist of everything from groups of cells even down to individual cell.

Read about the research at the Knight Cancer Precision Biofabrication Hub, who uses Biopixlar to study cancer development on a single-cell level.

https://www.cancerbiofabrication.com/

Liver models

The liver plays a central role during drug development because of its function in drug metabolization.

We have used Biopixlar to create a bioprinted composite in vitro model that improves the hepatocyte function compared to conventional cell culture. The 3D liver model is quick to assemble and easy to scale up to allow parallel bioassays.

The composite liver model features detailed arrangements of hepatocytes and fibroblasts that help to promote hepatocyte functionality. The detailed patterning is made possible by Biopixlar’s high precision cell deposition capabilities.

Download our application note.

Artificial pancreatic islets

At Fluicell, we use the power of Biopixlar to develop artificial pancreatic islets that consists of a combination of alpha-, beta- and support cells, facilitating full euglycemic control.

In the islet production, we rely on Biopixlar’s capacity for precise cell placement to produce islets with a size and composition the resemble the native Islets of Langerhans.

Read more about Fluicell’s ongoing development of tissue-based type 1 diabetes therapeutics in our white paper.

Neuron networks

The combination of precise cell placement and cell-friendly bioprinting condition makes Biopixlar ideal for printing sensitive cells like neurons. Here, we have created a cluster of acutely isolated primary rat dorsal root ganglia (DRG) neurons, printed directly using Biopixlar.

With Biopixlar, you can place cells where you want them to promote intercellular connections and create complex cellular patterns, making the platform a powerful tool for neuroscience research.

Read more in our neuron bioprinting flyer.

The Biopixlar platforms

Biopixlar

The original single-cell 3D bioprinter. Using high-performance microfluidic direct cell deposition and with a wide range of add-on options, Biopixlar is a powerful research platform capable of producing everything from single cell arrays to organoids and complex tissues.

Learn more

Biopixlar AER

Powerful and ultra compact. Biopixlar AER is the first single-cell bioprinting platform that fits into a biosafety cabinet and is designed to bring you all the power of Fluicell’s open volume microfluidic bioprinting technology in a streamlined platform built for easy workflow integration.

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The Biopixlar advantage

	Biopixlar	Extrusion	Stereolithography	Inkjet	Laser assisted
Printing resolution	+++	+	++++	++	++
Small volume capacity	++++	+	++	+++	+++
Throughput	++	+++	+	++++	+
Fast sample preparation	++++	++	++	+++	+
No carrier material required	++++	+	+	++	+
Cell stress prevention	++++	+	++	+++	+++
Cell on cell printing	++++	+	+	+	+
No need for crosslinking	++++	+	++++	+++	++++
Cell confluency post printing	++++	++	++	+++	++
Large tissue models	+	++++	+++	+	++
Cell to non-carrier material interaction	++++	+	+	+++	+
Tissue cell to cell interaction	++++	+	+	+++	+