Promising new insights into ion channel function

Researchers at Genentech Inc. have studied the structure and function of voltage-gated sodium channels, using Dynaflow Resolve to measure how the activity of the ion channels is affected when exposed to toxin. Their impressive results are presented in the paper entitled “Structural basis of α-scorpion toxin action on Nav channels”, published in Science.

Voltage-gated sodium channels are critical for electrical signaling in the body and are involved in a wide range of different conditions, including pain, epilepsy and muscle paralysis. The study provides a template for the design of Nav channel modulators and cold lead to the discovery of new drugs that target these conditions. We are very happy to see the great work by the researchers at Genentech Inc. and are honored they have chosen to use Dynaflow Resolve in their work on Nav channels.