Single-cell analysis of CXCR4 Receptor signaling

Chemokine receptors are important components in sell signaling, fulfilling a wide range of biological functions. In the paper Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4, recently published in the journal Molecular Pharmacology, Prof. Carsten Hoffmann and coworkers at University Hospital Jena use BioPen to investigate the activation of the chemokine receptor CXCR4 by the chemokine ligand CXCL12 on a single-cell level.

The CXCR4/CXCL12 pair is an well-established pharmaceutical target for cancer treatment and the work by Prof. Hoffmann and coworkers provide important insights into the complex mechanisms involved in receptor activation and how that affects cell signaling. The detailed insight into receptor activation that their work provide can facilitate the development of new, more specific, drugs against this target.

We are very happy the see the impressive work from Prof. Hoffmann and coworkers and are grateful that they have chosen to use BioPen in their important research.

Watch a video on sensing receptor activation using intramolecular FRET on our YouTube channel.

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