- February 5, 2018
Our ion channel receptor systems are very slow, how does this chip help us?
Experimental control is an important issue. With the Dynaflow® resolve system, you always know the true molecular composition…
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Which ion channels can be used with the Dynaflow® Resolve system?
Both voltage and ligand gated ion channels, the system is very flexible.
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Screening desensitising receptor systems for several different substances, is that ok?
By adding agonist free buffer in every other channel of the chip, an intermittent wash out between each…
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How is the cell affected by repeated substance stimuli?
Using the Dynaflow® Resolve technology you have unprecedented control of the following parameters: – The composition of the…
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How many substances can be screened per day with the platforms available today?
The number of substances one can screen per day with the Dynaflow® Resolve system depends very much on…
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Is it possible to screen substances with or without re-sensitisation of receptor responses?
Yes, it is possible to screen substances with or without re-sensitisation of receptor responses.
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During which phases of the drug development process is the system applicable? Characterization and validation.
Concentration response curves, (EC50, IC50), receptor kinetics, receptor activation, thermodynamics of ligand binding. Dynaflow® Resolve is used for…
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